Table 2.
Summary of chromosome changes in second-generation black and white variants collected in culture and from infected mice.
| Starting strain/color | Aberrant chromosome | 2nd Generation straina/pigment | Aberrant chromosome(s) |
|---|---|---|---|
| Strains collected in culture | |||
| White to black | |||
| W2/white | Chr 13 | W2-BA/black | Chr 13, 4, 12 |
| W2/white | Chr 13 | W2-BB/black | Chr 13, 12b |
| W3/white | Chr 13 | W3-BB/black | Chr 13, 4 |
| W3/white | Chr 13 | W3-BC/black | Chr 13, 12 |
| White to white | |||
| W2/white | Chr 13 | W2-WB/white | Chr 13 (3, 5, 12, 14)b |
| Black to white | |||
| B1/black | none | B1-WA/white | Chr 3b, 11b |
| B1/black | none | B1-WB/white | Chr 13 (3, 5, 11)b |
| B1/black | none | B1-WC/white | Chr 13, 5b, 6 |
| Strains collected from mice | |||
| White to black | |||
| W2/white | Chr 13 | W2-MB3/black | Chr 13, 4 |
| W2/white | Chr 13 | W2-MB4/black | Chr 13, 4 |
| W2/white | Chr 13 | W2-MB5/black | none |
| W2/white | Chr 13 | W2-MB7/black | Chr 13, 4, 12 |
| W2/white | Chr 13 | W2-MB8/black | Chr 13, 4 |
| W3/white | Chr 13 | W3-MB13/black | Chr 4, 14b |
| W3/white | Chr 13 | W3-MB16/black | none |
| White to white | |||
| W2/white | Chr 13 | W2-MW1/white | Chr 13 |
| W2/white | Chr 13 | W2-MW2/white | Chr 13 |
| W3/white | Chr 13 | W3-MW6/white | Chr 13 |
| Black to white | |||
| B6/black | none | B6-MW10/white | none |
| B6/black | none | B6-MB20/white | none |
aThe second generation strains are named after the starting strain followed by the color (B = black and W = white) and a letter or number designation. In the case of strains collected from mice, an M is added before the letter indicating color.
bThese chromosomes show segmental changes. Note that some chromosomes show an elevated copy number but not full disomy perhaps indicating variability among cells in the population.