Figure 2.

Rat GPe neuron morphology and location of effective synapses. Effectiveness of synapses was determined in a modeling study by measuring the mutual information between synaptic input at each location and output spikes (Edgerton et al., 2010). When spike initiation was entirely axonal (left), only synapses close to the soma were effective. In contrast, when spike initiation was entirely dendritic (right) only distal synapses were effective. With intermediate dendritic NaV channel densities the locations of effective synapses was more evenly distributed. Adapted from (Edgerton et al., 2010)