A, Schematic representation of the UNC5C gene showing exon-intron structure, location of CpG island, protein domains, and sequence changes observed in this study. Above the sequence are 7 missense changes. Those 4 not already described in databases are depicted in color. B, Table recapitulating the different newly identified missense variations. AA : Amino acid. C, Table showing the conditional maximum likelihood estimate of the odds ratio (OR), associated Wald’s 95% confidence interval (CI), and p-values as obtained with Fisher’s exact text.