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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Gastroenterology. 2011 Sep 3;141(6):2039–2046. doi: 10.1053/j.gastro.2011.08.041

Figure 2. Pedigrees of the 5 families in which the proband had a deleterious A628K mutation in UNC5C.

Figure 2

A, Four-color-sequencing chromatograms from an automated DNA sequencer showing the germline missense mutation in the UNC5C gene from a patient (Family 1, III.3), and a control sequence (Caucasian control population). The coding strand is shown. M: C and A, R: G and A. B, The probands screened for UNC5C mutations are indicated by red arrows. Individuals with cancer are shown as filled circles/squares. Different cancers are indicated beneath the relevant individuals, with age at diagnosis next to the cancer type. WT, normal sequence observed; The A628K mutation in UNC5C gene is indicated beneath individuals. Absence of a genotype indicates that DNA samples could not be obtained. BC (Breast Cancer). CaSU (Cancer Site Unknown). Crohn s (Crohn s disease). CRC (Colorectal Cancer). H&N (Head&Neck cancer). Roman numerals refer to generations, and individuals within a generation are numbered from left to right. Families origin: USA (USA), France (F), France and Portugal (F-P).