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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: J Hepatol. 2011 Apr 14;55(6):1281–1290. doi: 10.1016/j.jhep.2011.03.017

Figure 4. Hepatic overexpression of cPLA2α protects the liver from Fas-induced apoptosis (16 hours after Jo2 injection).

Figure 4

The cPLA2α Tg mice and their age/sex-matched wild type mice were intraperitoneally administered with 0.25 μg/g body weight of Jo2 and the animals were sacrificed 16h after Jo2 injection. The liver tissues were harvested for histological evaluation and caspase activity assay. (A) Formalin-fixed and paraffin-embedded sections (5 μm thick) were stained with H&E (Magnification x 100). The wild type mice showed more prominent hepatocyte apoptosis and liver injury when compared to the cPLA2α Tg mice. (B) The number of TUNEL-positive hepatocytes in the wild type mice was significantly higher than that in the cPLA2α Tg mice. The data are expressed as means ±standard deviation from six mice per group (*p<0.01). (C) The activity of caspase 3 in the wild type mice was significantly increased compared with the cPLA2α Tg mice (*p<0.01).