Figure 8.
CEP-modified protein is detected in the brains of all autism cases while no specific labeling is seen in controls. Representative cases of autism aged 9, 7, and 5 years (D, E, F) and controls aged 5, 6, and 11 years (A, B, C) are shown. In some autism cases, CEP is also present in neuronal cell bodies (D). Scale bar = 50 μm. This research was originally published in Am J Biochem Biotech. Evans, T. A., Siedlak, S. L., Lu, L., Fu, X., Wang, Z., McGinnis, W. R., Fakhoury, E., Castellani, R. J., Hazen, S. L., Walsh, W. J., Lewis, A. T., Salomon, R. G., Smith, M. A., Perry, G. and Zhu, X. (2008) The Autistic Phenotype Exhibits a Remarkably Localized Modification of Brain Protein by Products of Free Radical-Induced Lipid Oxidation. Am J Biotech Biochem 4, 61–72. © Science Publications.