Skip to main content
. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: J Immunol. 2011 Oct 26;187(11):5500–5504. doi: 10.4049/jimmunol.1102357

Figure 2. CaMKIV suppresses cell cycle arrest of lupus MCs.

Figure 2

(A) and (B) MCs were stained by propidium iodide (PI) and cell cycle analysis was performed by flow cytometry. 400,000 MCs derived from MRL/MPJ and MRL/lpr mice were treated with or without KN-93 for 48 hrs and stimulated with or without PDGF-BB for 24 hrs. Cumulative data of flow cytometry (percentage of cells in each cell cycle phases) are shown from (A) unstimulated and (B) PDGF-BB-stimulated MCs. Values are the mean ± SD of n=4–5 mice/group and performed in three independently replicates. (C) 400,000 MCs derived from MRL/MPJ, MRL/lpr and MRL/lpr.Camkiv−/− mice were stimulated with or without PDGF-BB for 24 hrs. Cumulative data of flow cytometry (percentage of cells in each cell cycle phases) are shown. Values indicate mean ± SD of n=4–5 mice/group performed in three independently replicates.