Fig. 1.
Impact of chronic neuroinflammation on neurogenesis and the migration of adult-born neurons two months after LPS infusion terminated. (A) Numbers of activated microglia (OX-6 immunoreactive) within the DG of aCSF- and LPS-treated rats (***p=0.0001 vs. aCSF). (B) The number of BrdU-labeled neurons in the DG enclosed blade did not significantly differ between aCSF-treated and LPS-treated animals (p=0.7577). (C) Index of migration calculated as im = m / w × 100, “m” is the distance between the center of the nucleus and the subgranular zone; “w” is the width of the granule cell layer. (D) The index of migration was higher in LPS-treated rats than in aCSF-treated rats (*p=0.0192).