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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: J Immunol. 2011 Nov 2;187(11):5813–5823. doi: 10.4049/jimmunol.1101068

Figure 6. IL-1β is not responsible for greater inflammation, increased numbers of Th17 cells and decreased numbers of Treg cells in the skin of TPA-treated Pglyrp1−/−Pglyrp2−/− mice.

Figure 6

(A) Ear swelling in Pglyrp1−/ −Pglyrp2−/ − mice treated with TPA on days 0, 2, 4, and 6, and also treated with either isotype control IgG or neutralizing anti-IL-1β mAbs; means ± SEM. (B) Percentages of Th17 and Treg cells in the ears of Pglyrp1−/ −Pglyrp2−/ − mice on day 9 after application of TPA to the ears on days 0, 2, 4, 6, and 8 measured by flow cytometry; means ± SEM. (C) Representative dot plots for Th17 and Treg cells. N = 7 mice/group; all differences between IgG control and anti-IL-1β mAbs-treated mice were not significant (NS, P>0.05).