Table II.
PK parameters by age group (PPK population)
| Parameter | Children | Adolescents | Adults |
|---|---|---|---|
| 2–11 years | 12–15 years | 16–64 years | |
| N = 9 | N = 3 | N = 11 | |
| Cmax (g/L), mean (SD) | 8.09 (1.492) | 8.60 (1.443) | 8.31 (1.096) |
| Tmax (day), median (range) | 2.06 (0.94–6.92) | 1.98 (1.93–2.94) | 2.07 (0.95–3.98) |
| AUC (day × g/L), mean (SD) | 52.30 (9.987) | 54.91 (11.548) | 54.52 (8.672) |
PPK per-protocol pharmacokinetic, N number of patients in age group, Cmax maximum concentration, Tmax time point of maximum concentration, AUC area under the concentration–time curve until last measured concentration, SD standard deviation