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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: J Hepatol. 2011 Apr 13;55(6):1256–1262. doi: 10.1016/j.jhep.2011.03.014

Figure 6.

Figure 6

A cartoon representing the configuration of AJ and TJ in β-catenin KO liver (left) and normal liver (right). While β-catenin bridges E-cadherin to F-actin in the WT livers, this function is compensated by γ-catenin in absence of β-catenin. β-Catenin and γ-catenin are both able to translocate to the nucleus, however β-catenin has robust nuclear interactions with TCF/LEF and hence transactivates expression of genes such as claudin-2, which is a means of crosstalk between AJ proteins and TJ components. However in KO, loss of claudin-2 impacts JAM-A and claudin-1 expression, which may affect TJ functions.