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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: J Immunol. 2011 Oct 31;187(11):5921–5930. doi: 10.4049/jimmunol.1100746

Fig. 4.

Fig. 4

Glyphosine stimulates IL-10 production from NOD splenocytes. (A) IL-10 Elispot with 500 nm glyphosine. Number of spots for each well is shown in the upper left hand corner. (B–C) Ex vivo IL-10 and IFN-γ Elispot assays from 10 week old female NOD mice treated with 80 mg/kg/day of glyphosine by intraperitoneal administration for 5 days. IL-10 is increased with glyphosine while IFN-γ spot number remains unchanged. *p=0.014. (D) IL-10 Elispot assays from mice with differing I-A molecules. *p=0.011, **p=0.008. Each bar represents the mean spot number of triplicates ± SEM. from at least four mice per group. (E) Glyphosine treatment prevents diabetes development. Survival curve of a diabetes prevention study in 4 week old NOD mice obtained from Jackson Laboratories. The glyphosine treated mice are statistically different (p<0.001) compared to controls receiving phosphate buffered saline.