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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: J Immunol. 2011 Oct 21;187(11):5756–5763. doi: 10.4049/jimmunol.1102133

FIGURE 5.

FIGURE 5

IgE, AHR and goblet cells in sensitized mice exposed to HDM and rapamycin. A: Rapamycin attenuated HDM-induced IgE. n = 4–11 mice per group. *p<0.05 vs. Saline/Saline, #p<0.05 vs. HDM/Saline, ^p<0.05 vs. HDM/HDM. B: Rapamycin blocked HDM-induced increases in AHR after methacholine challenge. n = 3–10 mice per group in two independent experiments. *p<0.05 vs. Saline/Saline, HDM/Saline, ^p<0.05 vs. HDM/HDM. C: Western blot analysis shows that rapamycin attenuated HDM-induced increases in CLCA3. n = 3 to 4 mice per group. *p<0.05 vs. HDM/Saline, ^p<0.05 vs. HDM/HDM. D: Q-RT-PCR analysis revealed decreased Muc5AC mRNA expression after HDM challenge in lungs of rapamycin treated mice. Gene expression was normalized to β-actin. n = 3–5 mice per group. Samples were run in triplicate. *p<0.05 vs. HDM/Saline, ^p<0.05 vs. HDM/HDM. E: Rapamycin reduced Muc5AC immunostaining in airways of HDM/HDM mice. On 10X panels, sale bar equals100µm.