Table 1.

Composition of PCCs in the World Federation of Hemophilia register of clotting factor concentrates

		International units relative to factor IX
		Factor	Factor	Factor	Factor		Additional
Brand name	Manufacturer	II	VII	IX	X	Viral inactivation	information
Bebulin VH	Baxter BioScience, Austria	120	(13)	100	100	Vapour heat, 60°C for 10 hours at 190 mbar, then 80°C for 1 hour at 375 mbar	Heparin added
Beriplex P/N	CSL Behring, Germany	128	68	100	152	Pasteurisation at 60°C for 10 hours, and nanofiltration	Protein C; antithrombin, heparin and albumin added
Cofact	Sanquin, the Netherlands	56-140	28-80	100	56-140	Solvent/detergent and 15 nm nanofiltration	Antithrombin added
KASKADIL	LFB, France	148	40	100	160	Solvent/detergent	Heparin added
Octaplex	Octapharma, Austria and France	44-152	36-96	100	50	Solvent/detergent and nanofiltration	Heparin added; low activated factor VII content
Profilnine SD	Grifols, USA	148	(11)	100	64	Solvent/detergent	-
Prothrombinex VF	CSL Bioplasma, Australia	100	(-)	100	100	Dry heat, 80°C for 72 hours and nanofiltration	-
Prothromplex T	Baxter BioScience, Austria	100	85	100	100	Vapour heat, 60°C for 10 hours at 190 mbar, then 80°C for 1 hour at 375 mbar	Antithrombin and heparin added
UMAN Complex D.I.	Kedrion, Italy	100	(-)	100	80	Solvent/detergent and dry heat, 100°C for 30 minutes	Antithrombin and heparin added

Composition of prothrombin complex concentrates (PCCs) listed in the World Federation of Hemophilia register of clotting factor concentrates [54], excluding concentrates for national markets only or for which the concentrations of factors relative to factor IX were not available from the relevant product information sheets. Factor VII presented in parentheses for three-factor PCCs.