Table 2.
Diagnosis, antifungal therapy, and patient outcomes in IBPA group
| Class of diagnosis | Type | Risk factors | Chest CT scan | Chest x-ray | BSP | Serum IgE (KU/L) | Asp Ab | Fungal culture | Aspergillus species | Histology | Previous antifungal prophylaxis | Antifungal therapy | GM detection 0.5 ng/ml a | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Probable | IPA | Steroids and antibiotics | Nodule, patching | Patching, consolidation | 513 | Positive | ETA (1) | A. fumigatus | No | ABLC | Negative | ||
| 2 | Proven | ATB and IPA | Steroids and antibiotics | Nodule, consolidation, halo sign | Patching, nodule | PM | 33 | Negative | ETA (2); BALF (5) | A. fumigatus | Positive | No | ABLC and voriconazole | Positive |
| 3 | Probable | IPA | Steroids and antibiotics | Nodule, patching, consolidation | Patching | 209 | Positive | Spu (5) | A. fumigatus | Yes | ABLC and voriconazole | Positive | ||
| 4 | Probable | IPA | Steroids and antibiotics | Negative | 51 | Negative | Spu (2) | A. fumigatus | No | ABLC and itraconazole | Negative | |||
| 5 | Proven | ATB | Steroids and antibiotics | Negative | PM | 148 | Positive | ETA (9); BALF (1) | A. fumigatus and A. flavus | Positive | No | ABLC | Positive | |
| 6 | Probable | IPA | Steroids and antibiotics | Patching, nodule, consolidation | 14 | Negative | ETA (12) | A. fumigatus | No | ABLC and voriconazole | Positive | |||
| 7 | Possible | IPA | Antibiotics | Patching, nodule, cavitation | Patching, nodule, consolidation, cavitation | 15 | Negative | No | No | No | Caspofugin and voriconazole | Negative | ||
| 8 | Probable | IPA | Steroids and antibiotics | Patching | 4 | Negative | ETA (2) | A. fumigatus | No | No | Positive | |||
| 9 | Probable | IPA | Steroids and antibiotics | Nodule, consolidation | 67 | Negative | Spu (3) | A. flavus | No | ABLC | Negative | |||
| 10 | Probable | IPA | Steroids and antibiotics | Patching, nodule, consolidation | Patching, nodule, consolidation | 29 | Negative | Spu (3) | A. niger | No | ABLC and voriconazole | Positive | ||
| 11 | Proven | ATB and IPA | Antibiotics | Nodule, consolidation | Patching, nodule, consolidation | PM | 89 | Positive | Spu (3) | A. niger | Positive | Yes | ABLC and caspofugin | Negative |
| 12 | Proven | ATB and IPA | Steroids and antibiotics | Patching | PM | 107 | Negative | BALF (5) | A. fumigatus | Positive | No | ABLC | Positive | |
| 13 | Probable | IPA | Antibiotics | Patching, consolidation | 260 | Positive | ETA (2) | A. fumigatus | No | ABLC | Negative |
ABLC, amphotericin B lipid complex; Asp Ab, serum Aspergillus antibody; ATB, Aspergillus tracheobronchitis; BALF, bronchoalveolar lavage fluid; BSP, bronchoscopy; ETA, endotracheal aspiration; GM, galactomannan; IgE, immunoglobulin E; IPA, invasive pulmonary aspergillosis; PM, pseudomembrane; Spu, sputum. "number" in the fungal-culture column, times of positive cultures. aPositive means one positive in any of the three samples.