Table 5.
Parameter | OR (95%CI) | Adjusted OR (95%CI) | P-value |
---|---|---|---|
Lack of AT protocol | 1.4 (0.9 to 2.2) | 1.64 (1.01 to 2.69) | 0.04 |
Age ≥60 | 2.6 (1.6 to 4.1) | 1.97 (1.19 to 3.26) | 0.008 |
SAPS II score on admission ≥38 | 4.5 (2.5 to 7.5) | 2.78 (1.60 to 4.84) | <0.0001 |
Rapidly fatal underlying disease | 3.2 (1.8 to 5.8) | 2.91 (1.52 to 5.56) | 0.001 |
SOFA score at the beginning of AT ≥6 | 6.2 (3.5 to 10.9) | 4.48 (2.46 to 8.18) | <0.0001 |
Immunosuppression | 1.8 (1.1 to 3.4) | --- | 0.26 |
Inappropriate AT | 0.6 (0.3 to 1.3) | --- | 0.19 |
Septic shock | 3.1 (1.9 to 4.9) | --- | 0.26 |
University teaching hospitals | 0.7 (0.5 to 1.1) | --- | 0.23 |
Data are presented in the patients receiving new AT (n = 509). CI, confidence intervals; OR, odds-ratio; Rapidly fatal underlying disease (death <1 year) according to the McCabe score, see material and methods section; SAPS II, simplified acute physiology score II; SOFA, sequential organ failure assessment; AT, antibiotic therapy.