Table 5.

Univariate and multivariate analysis of predictive factors of mortality

Parameter	OR (95%CI)	Adjusted OR (95%CI)	P-value
Lack of AT protocol	1.4 (0.9 to 2.2)	1.64 (1.01 to 2.69)	0.04
Age ≥60	2.6 (1.6 to 4.1)	1.97 (1.19 to 3.26)	0.008
SAPS II score on admission ≥38	4.5 (2.5 to 7.5)	2.78 (1.60 to 4.84)	<0.0001
Rapidly fatal underlying disease	3.2 (1.8 to 5.8)	2.91 (1.52 to 5.56)	0.001
SOFA score at the beginning of AT ≥6	6.2 (3.5 to 10.9)	4.48 (2.46 to 8.18)	<0.0001
Immunosuppression	1.8 (1.1 to 3.4)	---	0.26
Inappropriate AT	0.6 (0.3 to 1.3)	---	0.19
Septic shock	3.1 (1.9 to 4.9)	---	0.26
University teaching hospitals	0.7 (0.5 to 1.1)	---	0.23

Data are presented in the patients receiving new AT (n = 509). CI, confidence intervals; OR, odds-ratio; Rapidly fatal underlying disease (death <1 year) according to the McCabe score, see material and methods section; SAPS II, simplified acute physiology score II; SOFA, sequential organ failure assessment; AT, antibiotic therapy.