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. 2011 Nov 18;9(1):51–58. doi: 10.7150/ijms.9.51

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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D-Lys3-GHRP-6 inhibits SDF-1-, MIP-1α-, MIP-1β- and RANTES-induced intracellular calcium release from CEM-CCR5 cells. CEM-CCR5 cells were loaded with Fura-2-AM dye, washed, treated with different concentration of DLS for 20 minutes and 1.5 ml cells used to read for calcium release after addition of chemokine in luminescence spectrometer. Each graph shows the 340nm/380nm excitation ratio at 509nm absorption. It shows CEM-CCR5 cells' calcium release after addition of MIP-1β (60nM), MIP-1α (60nM) and RANTES (10nM). The data reveals that, DLS partially inhibits MIP1β, MIP1α and RANTES induced calcium release (range of 10-40% inhibition).