Table 1.

Plant HDPs and their multiple activities related to host-protection.

Peptide name	Source	Activity	Possible application	Reference
DEFENSINS
–	Phaseolus angularis	Inhibit tumor cell lines L121 and MBL2	Antitumor therapy	Ma et al. (2009)
Limenin	P. limensis	Inhibit myeloma (M1) and leukemia (L1210) cell lines and inhibit HIV-1 reverse transcriptase	Antitumor and antiviral therapy	Wong and Ng (2006)
Lunatusin	P. lunatus	Inhibit breast cancer cell line (MCF-7), the activity of HIV-1 reverse transcriptase, and the translation in a cell-free rabbit reticulocyte lysate system	Antitumor and antiviral therapy	Wong and Ng (2005)
–	P. vulgaris	Inhibit hepatom (HepG2), breast (MCF-7), colon (HT29), and cervical cancer (SiHa) cells, and inhibit HIV-1 reverse transcriptase activity	Antitumor and antiviral therapy	Lin et al. (2010)
THIONINS
Without name	Triticum aestivum	Inhibit the proliferation of Leishmania donovani	Leishmanicidal therapy	Berrocal-Lobo et al. (2009)
PTH1	Solanum tuberosum	Inhibit the proliferation of L. donovani	Leishmanicidal therapy
CYCLOTIDES
Kalata B1	Oldenlandia affinis	Uterotonic, anti-HIV activities, and anthelmintic activity against parasites of sheep, humans, and dogs	Anthelmintic, antiviral, and uterotonic therapy	Gran (1973), Colgrave et al. (2008), Colgrave et al. (2009)
Kalata B6	O. affinis	Anthelmintic activity against gastrointestinal parasites of sheep, humans, and dogs	Anthelmintic therapy	Colgrave et al. (2008), Colgrave et al. (2009)
CirA	Chassalia parvifolia	Anti-HIV activity	Antiviral therapy	Gustafson et al. (1994)
CirB	C. parvifolia	Anti-HIV activity	Antiviral therapy
Cyclopsychotride	Psychotria longipes	Ability to block neuropeptide neurotensin	Antipsychotic therapy	Witherup et al. (1994)
Cycloviolacin O2	Viola biflora	In vitro antitumor activity	Antitumor therapy	Gerlach et al. (2010)