FIGURE 4.
Mitochondrial ncRNAs are predominantly found as duplexes and show cell-specific expression. (A) Mitochondria isolated from HeLa cells were lysed and treated with either RNase A or RNase If, and lncRNAs and mRNAs were measured by ss qRT–PCR. Mitochondria not treated with RNases were used as a control. Differential abundance of lncRNAs compared with their coding counterparts in different cell lines determined from deep-sequencing data sets (B) and in 18 different human tissues (C) determined by ss qRT–PCR, suggesting that they may have a role in the regulation of mitochondrial gene expression.