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. Author manuscript; available in PMC: 2011 Nov 22.
Published in final edited form as: Science. 2011 Oct 14;334(6053):249–252. doi: 10.1126/science.1211057

Fig. 2.

Fig. 2

The effects of antibiotic treatment on poliovirus replication and pathogenesis. (A) Poliovirus replication kinetics in MEFs and HeLa cells +/- antibiotics. (B) Fecal bacterial loads from untreated or antibiotic-treated mice harboring antibiotic-resistant (abxR) bacteria. Feces were plated on rich medium +/- four antibiotics. (C) Survival of PVRtg-Ifnar1-/- mice orally inoculated with poliovirus pre-mixed with four antibiotics (Untreated+abx PV, n=9) or poliovirus alone in antibiotic-treated mice harboring AbxR bacteria (Abx+abxR, n=8). (Results from untreated and antibiotic-treated mice are from Fig. 1B.) (D) Replication of light-sensitive poliovirus in untreated mice receiving poliovirus+antibiotics inoculum and antibiotic-treated mice harboring abxR bacteria in comparison to antibiotic-treated mice. (Results from antibiotic-treated mice are from Fig. 1E.) Each symbol represents mean + SEM. A and B, N=2-5 experiments, C and D are from a representative experiment.