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. 2011 Dec 15;138(24):5441–5450. doi: 10.1242/dev.067280

Fig. 7.

Fig. 7.

PAR-1 functions in the Wnt5/11 pathway upstream of Pax3. (A) PAR-1 RNA promotes Pax3 expression (stage 17). (B) PAR-1 is required for Pax3 expression (stage 14/15). (C,D) PAR-1 rescues the FoxD3 defect in embryos that were injected with dnWnt5/11 RNA. Dorso-anterior view, except A (dorsal view). Arrows indicate altered gene expression. (E) Model for Wnt11R signaling during NC specification. Dvl and the associated PAR-1 protein kinase are essential regulators of NC-specific transcription in response to Wnt11R/Ror2 signaling. Dashed lines represent indirect effects via unknown intermediates.