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. Author manuscript; available in PMC: 2011 Nov 22.
Published in final edited form as: Am J Physiol Gastrointest Liver Physiol. 2008 Apr 17;294(6):G1441–G1449. doi: 10.1152/ajpgi.00588.2007

Fig. 3.

Fig. 3

Effects of abdominal vagal nerve application of lidocaine on the VMR to CRD in anesthetized rats. Data were collected from 6 vehicle control rats and 6 rats after topic lidocaine application. The VMR was quantified as the number of abdominal muscle contractions produced by graded-pressure CRD (A) and the mean amplitude, expressed as the AUC after baseline subtraction (B). CRD evoked a dose-dependent increase in VMR in lightly anesthetized rats; pressure threshold, however, was increased to 60 mmHg. Similar with the VMR to CRD in rats after chronic vagotomy, acute lidocaine treatment markedly enhanced VMR to CRD. *P < 0.05 compared with vehicle.