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. Author manuscript; available in PMC: 2011 Nov 22.
Published in final edited form as: ACS Chem Biol. 2010 Feb 19;5(2):233–243. doi: 10.1021/cb900232a

Figure 6.

Figure 6

(a) Comparison of in vivo fluorescent images of mice labeled with LP-1 and carrier-conjugated probes. Mice bearing C2C12/ras xenograft tumors were IV injected with LP-1 (top) or Penetratin LP-1 (middle) and Cholesterol LP-1 (bottom) probes and mice imaged at the indicated time points. Images are presented using a colorimetric scale based on photons per second per centimeter square per steradian (p s−1 cm−2 sr−1) overlaid on bright light images. (b) Ex vivo imaging of whole organs and SDS-PAGE analysis from the corresponding organ extracts. Fluorecent probe labeled proteins were visulaized by scanning of the gel using a flatbed laser scanner. The location of legumain (Leg) is shown. (c) Quantification of fluorescent signal in tumors (left) compared to tumor to normal tissue signal ratios (right).