. Author manuscript; available in PMC: 2011 Nov 22.

Published in final edited form as: ACS Chem Biol. 2010 Feb 19;5(2):233–243. doi: 10.1021/cb900232a

Table 1.

Inhibition of various cysteine proteases by LI-1 and LI-0.

	Legumain		Cathepsin B	Cathepsin L	Caspase-3
Inhibitor	IC₅₀	k_obs/[I]	IC₅₀	IC₅₀	IC₅₀
LI-1	11.5nM	72352 M⁻¹s⁻¹	390 μM	220 μM	890 μM
LI-0	704 nM	1586 M⁻¹s⁻¹	>1 mM	>1 mM	2.8 μM
JPM-OEt^a	N/D		0.78 μM	2.98 μM	N/D
Z-DEVD-FMK^b	N/D		N/D	N/D	0.13 μM

JPM-OEt is a broad-spectrum cathepsin inhibitor.

Z-DEVD-FMK is a caspase-3 specific inhibitor.