Figure 2.
Sustained α-galactosidase A (α-gal) serum levels are significantly lower in nonhuman primates (NHPs) than in mice. Juvenile male rhesus monkeys (R-9, R-10, R-11) and both male and female C57BL/6J mice were dosed intravenously with 2 × 1013 drp/kg AAV8-αgal. Serum samples were analyzed for α-gal over time. As expected, the sustained expression levels in male mice were significantly greater than those seen in female mice. Sustained levels in female mice were significantly greater than those seen in the juvenile male primates.