Figure 6.

Improvement in renal function following adeno-associated virus (AAV) vector administration. (a) Western blot analysis of angiotensinogen (Agt) in G6pase (−/−) and (+/+) mouse kidneys. Each lane represents an individual mouse. (b) Analysis of G6pase (−/−) mouse urine following administration of the indicated number of vector particles at 12 days of age (1 × 10¹³ vp/kg, except AAV2 5 × 10¹² vp/kg); urine sampled at the indicated ages. Number of mice per group as follows: AAV2 (n = 5), AAV2/7 (n = 5), AAV2/8 (n = 3), AAV2/9 at 6 months (n = 9), AAV2/9 at 12 months (n = 4), G6pase (+/+) at 6 months (n = 7), G6pase (+/+) at 0.5 months (n = 3), and G6pase (−/−) at 0.5 months (n = 4). Mean ± SD are shown.