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Effect of mucin and DNA concentrations on the adjuvant effect of mucolytics. Ratios of ensemble-averaged effective diffusivity (<Deff>) of CK30PEG10k/DNA NPs in sputum pretreated with mucolytics to <Deff>of the same carriers in untreated cystic fibrosis (CF) sputum, as a function of (a) DNA concentration in CF sputum or (b) mucin concentration in CF sputum. The trendlines are logarithmic fit of individual data. Mean ± SEM.
