Figure 7.

Phenotypes of adeno-associated virus (AAV) capsid-specific different CD8⁺ and CD4⁺ T-cell subsets. The average expression levels of PD1, Ki67 were determined on interferon-γ (IFN-γ) and/or interleukin-2 (IL-2) secreting (TCM⁺,TEM⁺,TEff⁺) and IFN-γ and IL-2 double negative (TCM⁻,TEM⁻,TEff⁻) CD8⁺ and CD4⁺ T-cell subsets in both nonhuman primate (NHP) and human peripheral blood mononuclear cells (PBMCs). (a) The expression levels in naive cell population are shown for comparison. (b–e) The geometric mean fluorescence intensity (GMFI) of PD1, Ki67 expression in different cell subsets are shown. The error bars show the SD of three to four different samples which had sufficient numbers of cells for the analysis in each group.