Table 1.
Base Case | Range Used in Sensitivity Analysis |
Sources | |
---|---|---|---|
Pre-transplantation | |||
| |||
Yearly percent chance of developing symptomatic ascites on waitlist | 20.3% | 10-40% | (32, 72, 73) |
Percent chance of receiving TIPS for ascites or bleeding | 20.5% | 5-40% | (32, 72, 74) |
Percent chance of death related to each TIPS procedure | 3.8% | 1-8% | (72, 74) |
Yearly percent chance of contracting SBP in patients with symptomatic ascites |
4.3% | 2-8% | (72, 75-78) |
Percent chance of death related to each episode of SBP | 20.0% | 10-40% | (72, 75, 77-79) |
Yearly percent chance of having encephalopathy requiring admission | 23.5% | 11-46% | (32, 80) |
Percent chance of death from each episode of encephalopathy | 11.5% | 5-25% | (81, 82) |
Yearly percent chance of developing HCC on waitlist | 10.3% | 5-20% | (32, 83) |
Yearly percent chance of in patients with HCC of progression resulting in delisting (equivalent to 5.4% per 90-days on the waiting list) |
21.7% | 10-40% | (32, 84) |
Yearly percent chance of variceal hemorrhage | 22.4% | 11-44% | (32, 85-87) |
Percent chance of death from each episode of variceal hemorrhage | 14.2% | 7-28% | (86-88) |
Yearly percent chance of remaining stable on waitlist, without complications | 18.7% | 9-36% | (89) |
Yearly percent chance of death once delisted for a contraindication to transplant |
32.4% | 16-64% | (90-93) |
| |||
Post DDLT | |||
| |||
Percent chance of DDLT recipient death within 30 days of transplant | 4.1% | 2-9% | (32, 94, 95) |
Percent chance of graft failure due to disease recurrence | 2.0% | 1-10% | (32) |
Percent chance of successful retransplantation in patient with graft failure secondary to recurrent disease |
24.9% | 12-50% | (32) |
Yearly percent chance of admission for non-biliary sepsis post DDLT | 9.9% | 4-20% | (96-98) |
Percent chance of death from each sepsis event after DDLT | 14.1% | 7-28% | (96-98) |
Percent chance of needing non-transplant, no-biliary reoperation more than 30 days after DDLT |
22.5% | 11-45% | (99) |
Percent chance of death after each non-transplant reoperation after DDLT | 10.5% | 1-20% | (99) |
Percent chance of a biliary complication after DDLT | 21% | 10-40% | (100-104) |
Probability of death from biliary complications after DDLT | 4.7% | 2-9% | (100, 101, 104, 105) |
Percent chance of receiving retransplantation in a recipient with biliary complications after DDLT |
4.8% | 2-9% | (102, 106, 107) |
Percent chance of requiring non-transplant reoperation in a recipient with biliary complications after DDLT |
8.0% | 4-16% | (100, 102, 104, 108) |
Percent chance of acute rejection severe enough for hospitalization after DDLT |
35.9% | 15-60% | (11, 109, 110) |
Percent chance of death from an episode of acute rejection after DDLT | 0.2% | 0.1-0.5% | (110) |
Percent chance of requiring retransplantation because of severe acute rejection after DDLT |
1.3% | 0.5-3% | (110) |
| |||
Post LDLT | |||
| |||
Donor | |||
| |||
Probability of donor death after LDLT procedure | 0.28% | 0.01-1% | (51-55) |
Probability of donor having major complications (Clavien grade 3 or 4) after LDLT procedure |
1.5% | 0.5-4% | A2ALL,(52-54, 56, 57, 111-116) |
Probability of donor having minor or major complications (Clavien grade 2 or greater) after LDLT procedure |
13% | 6-25% | (52-54, 56, 57, 111- 116) |
Recipient | |||
Percent chance of LDLT recipient death within 30 days of transplant | 4.6% | 2-9% | A2ALL, (31, 32, 117) |
Percent chance of graft failure due disease recurrence | 3.2% | 1.5-7% | A2ALL, (31, 118-122) |
Percent chance of successful retransplantation in patient with graft failure secondary to recurrent disease |
21.4% | 12-50% | A2ALL, (32) |
Yearly percent chance of recipient admission for non-biliary sepsis post LDLT | 9.9% | 4-20% | A2ALL, (31, 96-98) |
Percent chance of recipient death from each sepsis event after LDLT | 14.5% | 7-28% | A2ALL, (31, 96-98) |
Percent chance of recipient requiring non-transplant, non-biliary reoperation after LDLT |
22.5% | 11-45% | A2ALL, (31, 51, 112) |
Percent chance of recipient death after each non-transplant reoperation after LDLT |
10.5% | 1-20% | (99) |
Percent chance of a recipient biliary complication after LDLT | 37% | 15-60% | A2ALL, (31, 51, 104, 108, 117, 123, 124) |
Percent chance of recipient death from biliary complications after LDLT | 9.7% | 4-19% | A2ALL, (31, 100, 101, 104, 108, 117, 123, 124) |
Percent chance of receiving retransplantation in a recipient with biliary complications after LDLT |
4.9% | 2-10% | (100, 101, 104, 117, 123, 124) |
Percent chance of requiring non-transplant reoperation in a recipient with biliary complications after LDLT |
54.9% | 20-90% | A2ALL,(104, 117, 123, 124) |
Chance of having acute rejection severe enough for hospitalization after LDLT | 33.9% | 15-60% | A2ALL, (11, 109, 110, 122, 125) |
Percent chance of death from an episode of acute rejection after LDLT | 0.2% | 0.1-0.5% | A2ALL, (11, 110, 122, 125) |
Percent chance of requiring retransplantation because of rejection after LDLT | 1.3% | 0.5-3% | A2ALL, (11, 110, 122, 125) |