Table 3.
Base Case Utility | Utility Range | Sources | |
---|---|---|---|
Baseline Health State Utilities | |||
| |||
Utility of compensated cirrhosis (Childs B) | 0.71 | 0.44-0.98 | (40-47) |
Utility of decompensated cirrhosis (Childs C) | 0.56 | 0.30-0.67 | (40-47) |
Utility of recipient post liver transplantation | 0.80 | 0.63-0.87 | (41, 43, 45, 47, 127) |
Utility penalty accrued every month after transplant when donor dies secondary to donation complication. Donors are assumed to be in perfect health before donation. |
Recipient utility – 1.0 | 0.75-1.0 | Expert opinion |
Utility penalty accrued every month after transplant when donor has major complications secondary to donation complication (128). Donors are assumed to be in perfect health before donation. |
Recipient utility – 0.3 | 0.25-1.0 | Expert opinion |
| |||
Utility Tolls for Specific Events |
Percent Toll From
Baseline |
||
| |||
Monthly utility penalty for refractory ascites | −25% | 0-80% | (44) |
One-time utility penalty from TIPS | −25% | 0-80% | (42) |
One-time utility penalty for SBP. Based on utility for refractory ascites. |
−25% | 0-80% | (44) |
Monthly utility penalty for HCC | −10% | 0-50% | (41, 43, 44) |
Monthly utility penalty for encephalopathy | −25% | 0-80% | (42, 44) |
Monthly utility penalty for variceal bleeding | −25% | 0-80% | (42, 44) |
One-time utility penalty for recent major surgery | −20% | 0-80% | (58) |
Monthly utility penalty for major complication of transplantation | −25% | 0-80% | (41, 43, 45, 47, 127) |
One-time utility penalty for undergoing DDLT | −50% | 25-75% | (41, 43, 45, 47, 127) |
One-time utility penalty for undergoing LDLT. Includes combined donor and recipient penalties |
−75% | 25-90% | (41, 43, 45, 47, 127) and expert opinion |