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. 2011 Nov 1;10:133. doi: 10.1186/1476-4598-10-133

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Copyright ©2011 Xu et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ad.SPDD-HCCS1 induces mitochondrial-mediated apoptosis in liver cancer cells. (A) Western blot analysis of apoptosis-related proteins in Huh-7 cells infected with Ad.SPDD, Ad.SPDD-HCCS1 or Ad.SPDD-HCCS1HA. Actin was used as a loading control. (B) Ad.SPDD-HCCS1 and Ad.SPDD-HCCS1HA induced an increased loss of mitochondrial membrane potential in Huh-7 cells. The mitochondrial membrane potentials of the Huh-7 cells infected with the indicated viruses were analyzed by JC-1 staining via FACS detection. The percentage of cells in the trapeziform region is shown as cells with lost mitochondrial membrane potential.