Table 1. Thirty-two G. pallidipes secretome proteins uniquely expressed in hypertrophied salivary glands.
Mol. wt range | Description of the proteins expressed in high abundance in hypertrophied salivary glands | ||
Protein Name | Accession No. | Functional annotation | |
<26 kDa | Bis-(5′-nucleosyl)-tetraphosphatase | XP_001969373.1 | DNA replication, metabolic stress and apoptosis |
Niemann-Pick TypeC-2 | ADD20212.1 | Mesoderm development | |
RNA polymerase II - BTF3 | ADD19794.1 | Transcription | |
deoxyUTP-pyrophosphatase | ADD20717.1 | Chromosomal integrity | |
Transitional ER ATPase | XP_002016299.1 | Molecular chaperones | |
ADP-ribosylation factor 1 | ADE42873.1 | Vesicle coat protein assembly | |
DNA replication factor/protein phosphatase inhibitor SET/SPR-2 | ADD19576.1 | Movement of histones; nucleasome assembly; chromatin fluidity | |
GTPase -binding nuclear protein Ran/TC4/gSP1 | ADD18812.1 | Nuclear transport and DNA replication | |
Cu/Zn-superoide dismutase | ADD19264.1 | REDOX processes | |
26–43 kDa | Ras-like GTP-binding protein Rho1 | ADD18925.1 | Control of cytoskeletal changes |
Proteasome activator complex subunit 3 | ADD19370.1 | Binds to 20S proteasome | |
Aldo/keto reductase | ADD18539.1 | Oxidoreductase activities | |
26S proteasome non-ATPase regulatory complex | ADD18827.1 | Integrity of 26S proteasome complex | |
Quiescin-sulfhydryl oxidase4 | XP_002048727.1 | Localized in high concentrations in cells with heavy secretory load | |
43–55 kDa | Serine protease inhibitor4 | ABC25075.1 | Chaperoning; Toll signalling |
60s acidic ribosomal protein P0 | ADD19996.1 | Proteins synthesis | |
S-adenosylmethionine synthetase | ADD19751.1 | Supplies metabolic methyl groups by catalyzing synthesis of AdoMet | |
ATP-dependent RNA helicase | XP_001968815.1 | Splicing and ribosome biogenesis | |
Vacuolar ATPase-S1 Ac45 | ADD18511.1 | REDOX; NAD/NADH-binding | |
Imaginal growth factor-3 | ABC25095.1 | Chitinase-related GH18; interaction with surface glycoproteins | |
Hsp-cognate70Cb | CAB38172.2 | Protein folding | |
Yellow protein precursor | ADD19747.1 | Controls adult pigmentation | |
>55 kDa | Catalase | ADD20421.1 | Protection from peroxides |
Hsp70/Hsp90 organizing protein | ADD19147.1 | Protein-protein interactions; chaperoning; transcription; protein transport complexes | |
Juvenile hormone esterase | ADD18773.1 | Hydrolase | |
Hsp60 (GroEL chaperonin) | ADD20133.1 | Productive protein folding | |
Angiotensin-converting-enzyme | XP_002002462.1 | Membrane-located metallopeptidase | |
Amidophosphoribosyltransferase | XP_002083899.1 | Purine biosynthesis | |
Lysosomal-α-manosidase | ADD18519.1 | Carbohydrate metabolism | |
C1-Tetrahydrofolate synthase | ADD18346.1 | Carbon metabolism | |
Endocytosis/signalling protein EHD1 | ADD19069.1 | Endocytosis; vesicle transport; signal transduction | |
Gamma-glutamyl phosphate reductase | ADD19821.1 | L-proline biosynthetic pathway |
The thirty-two G. pallidipes proteins expressed in high abundance in the hypertrophied SGs at all the time points (0, 48, 72 and 96 hpf) but were either detected in very low abundance or not detectable at all in the non-hypertrophied salivary glands.