Table 1. Functional classification of the upregulated/downregulated genes identified during the transition to lipid accumulation.

	Number of genes up/downregulated during each transcriptomic phase
Functional category	A	B	C
Amino acid metabolism	11/6	4/12	15/3
Carbohydrate metabolism	8/4	4/9	10/4
Catabolism	0/5	3/2	6/1
Cell cycle	12/10	4/17	34/3
Cellular aromatic compound metabolism	7/1	2/5	2/0
Cellular component biogenesis	34/4	1/25	14/3
Cellular component organization	52/17	11/51	64/12
Cellular metabolism	16/4	7/15	14/7
Lipid metabolism	2/3	1/12	17/0
Nucleic acids metabolism	48/14	5/39	46/8
Protein metabolism	1/1	0/1	5/0
Protein modification	13/8	4/16	19/4
Response to stimulus	20/12	10/24	36/5
Signalling	8/1	0/9	10/1
Transcription	7/7	3/7	20/3
Translation	74/2	1/52	10/1
Transport	29/22	14/28	42/8
Transposition	0/0	0/0	1/0
Vitamin metabolism	2/0	1/1	2/2
Unknown	37/45	30/65	119/27

(A) biomass production, (B) early lipid accumulation, and (C) late lipid accumulation. Functional categories were determined based on GO Terms defined during the annotation of Y. lipolytica, and by comparisons with homologous genes in S. cerevisiae.