Table 3.
Clinical Characteristics of CHARTER Cohort (n = 1560)
| Suicide Category [n(%)or mean(sd)] | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | A. No Depression Endorsed (n=579) | B.No Suicidal Ideation (n=352) | C. Thoughts of Death (n=224) | D.Thoughts of Suicide (n=99) | E. Made Suicide Plan (n=102) | F. Made Suicide Attempt (n=204) | Total (n=1560) | P-value | Pairwise Comparison |
| BDI-II Total Score | 10.1 (9.3) | 13.8 (9.6) | 15.4 (10.5) | 20.0 (10.7) | 19.2 (12.5) | 18.3 (11.7) | 14.0 (10.8) | <0.0001 | A<B,C<D,E,F |
| ARV Status | 0.13 | ||||||||
| Naïve | 92 (15.9) | 59 (16.8) | 28 (12.5) | 15 (15.2) | 8 (7.8) | 35 (17.2) | 237 (15.1) | ||
| HAART | 414 (71.5) | 251 (71.3) | 161 (71.2) | 69 (69.7) | 82 (80.4) | 131 (64.2) | 1108 (71.1) | ||
| No ARVs | 73 (12.6) | 42 (11.9) | 35 (15.6) | 15 (15.2) | 12 (11.8) | 38 (18.6) | 215 (13.8) | ||
| Current EFV | 0.003 | F< A,B,C,D,E | |||||||
| Yes | 129 (31.2) | 66 (26.3) | 52 (32.3) | 16 (23.2) | 18 (22.0) | 20 (15.2) | 301 (27.2) | ||
| No | 285 (68.8) | 185 (73.7) | 109 (67.7) | 53 (76.8) | 64 (78.0) | 111 (84.7) | 807 (72.8) | ||
| Regimen Type | 0.1 | ||||||||
| NNRTI-Based | 141 (34.1) | 86 (34.3) | 64 (39.8) | 24 (34.8) | 21 (25.6) | 28 (21.4) | 364 (32.9) | ||
| Pi-Based | 230 (55.6) | 134 (53.4) | 81 (50.3) | 36 (52.2) | 45 (54.9) | 88 (67.2) | 614 (55.4) | ||
| Other | 44 (10.4) | 31 (12.4) | 16 (10.9) | 9 (13.0) | 16 (19.5) | 15 (11.4) | 130 (11.7) | ||
| Current Psychotropics | <0.0001 | ||||||||
| No | 313 (54.4) | 135 (38.5) | 86 (38.4) | 30 (30.3) | 27 (26.5) | 51 (25.1) | 642 (41.3) | A>B,C,D,E>F | |
| Yes | 262 (45.6) | 216 (61.5) | 138 (61.6) | 69 (69.7) | 75 (73.5) | 152 (74.9) | 912 (58.7) | ||
| Est. Dur. Infec.(mos) | 118 (76) | 118 (76) | 123 (75) | 117 (66) | 133 (82) | 120 (78) | 120 (76) | 0.57 | |
| Current CD4 Count | 455 (291) | 445 (278) | 465 (303) | 493 (325) | 489 (265) | 470 (265) | 461 (287) | 0.36 | |
| Nadir CD4 Count | 211 (221) | 209 (189) | 192 (174) | 224 (205) | 192 (166) | 214 (161) | 208 (196) | 0.54 | |
| Log10 Plasma Viral Load | 2.7 (1.2) | 3.0 (1.3) | 2.9 (1.4) | 2.9 (1.4) | 2.7 (1.3) | 3.1 (1.3) | 2.9 (1.3) | 0.01 | A,E < B,C,D,F |
| HCV Status | 0.27 | ||||||||
| Positive | 158 (28.1) | 93 (27.0) | 50 (22.5) | 21 (21.4) | 22 (21.8) | 61 (30.0) | 405 (26.5) | ||
| Negative | 404 (71.9) | 251 (73.0) | 172 (77.5) | 77 (78.6) | 79 (78.2) | 142 (70.0) | 1125 (73.5) | ||
| Current MDD | <0.0001 | ||||||||
| No | 537 (95.2) | 297 (84.9) | 180 (80.4) | 71 (71.7) | 79 (77.5) | 152(74.9) | 1316 (85.3) | ||
| Yes | 27 (4.8) | 53 (15.1) | 44 (19.6) | 28 (28.3) | 23 (22.6) | 51 (25.1) | 226 (14.7) | D,F>E,C>B>A | |
| Lifetime Substance Abuse or Dependence | <0.0001 | ||||||||
| No | 203 (35.1) | 88 (25.0) | 52 (23.2) | 25 (25.3) | 24 (23.5) | 27 (13.2) | 419 (26.9) | ||
| Yes | 376 (64.9) | 264 (75.0) | 172 (76.8) | 74 (76.5) | 78 (76.5) | 177 (86.8) | 1141 (73.1) | A<B,C,D,E<F | |
| Quality of Life | |||||||||
| Mental Health | 74.3 (19.3) | 67.0 (19.4) | 63.5 (21.6) | 52.8 (21.5) | 58.9 (26.7) | 58.0 (22.2) | 66.6 (21.6) | <0.0001 | A>B>C, E>D>F |
| Physical Health | 72.7 (27.2) | 68.2 (27.2) | 66.3 (26.9) | 62.7 (26.1) | 63.7 (28.4) | 65.9 (28.3) | 68.7 (27.5) | <0.0001 | A>B,C,D,E,F |