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. Author manuscript; available in PMC: 2012 Nov 29.
Published in final edited form as: Biochemistry. 2011 Nov 7;50(47):10408–10417. doi: 10.1021/bi201321x

Table 3.

Compaction induced by transition state analogue binding revealed in the sedimentation rate of the MTAP complexes.a

Sample S(20,w) (normalized) S(20,w) relative change
MTAP 5.858 ± 0.021
MTAP + MT-DADMe-ImmA 5.904 ± 0.016 0.79 ± 0.05 %
MTAP + p-Cl-PhT-DADMe-ImmA 6.012 ± 0.067 2.63 ± 0.12 %
a

The sedimentation coefficients determined for replicate experiments were averaged and the relative change in sedimentation coefficients (S(20,w)) are reported. The S values of the complexes are normalized for the increased molecular mass of the bound ligands.