Fig. 1.

Schematic presentation of GH, IGF-1, and insulin signaling. IGF-1 insulin-like growth factor 1, GH growth hormone, IR insulin receptor, IGF1R insulin-like growth factor 1 receptor, GHR growth factor receptor, IRS-1 insulin receptor substrate 1, Shc Shc protein, GRB2 growth factor receptor-bound protein 2, PI3K phosphatidylinositol 3-kinase, Akt Akt protein, JAK2 Janus kinase 2, STAT5 signal transducer and activator of transcription 5, SOCS suppressor of cytokine signaling