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The TPVR- (A) and MBP- (B) response to 4-AP after pre-treatment with the peripherally restricted nAChR antagonist, ganglion blocker hexamethonium. Significant responses (* within symbol) during the initial response and after 25 min, were detected as indicated. Significant group differences were not detected. Hexamethonium reduced baseline MBP in both strains and also TPVR in SHR (Table 2). * – P ≤ 0.025.
