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. 2011 Nov 23;2:71. doi: 10.3389/fneur.2011.00071

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Copyright © 2011 Berg and Jensen.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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HR-response to 4-AP after removal of components of the adrenergic system. The rats were pre-treated to eliminate adrenal (AdrX) or neuronal (reserpine) catecholamines, peripheral β_1 + 2AR (peripherally restricted antagonist nadolol), or β₃AR-activity (β₃AR antagonist SR59230A). Reserpine and nadolol were also combined with mAChR antagonist (atropine), as indicated by symbol legends. Column graphs to the right shows HR_nadir during the initial response (1–2 min) and ΔHR at 25 min. Significant responses (* within column) and group differences (brackets) were located as indicated. Baseline HR was slightly reduced after reserpine and nadolol in WKY and clearly after nadolol in SHR (Table 2). * – P ≤ 0.025.