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The effect of the norepinephrine reuptake inhibitor desipramine on the HR-response to 4-AP. Significant responses (* within symbol) at HR nadir and at 25 min were located as indicated. A difference between the SHR control and the desipramine-treated group was detected at 10 min (* between curves). Baseline HR was not different after desipramine (Table 2). * – P ≤ 0.025 and 0.0167 for significant responses and group differences, respectively.
