Fig. 6.

K_A reduces response to fast ripple input. The first column represents the membrane potential of the soma. The second column represents the current through the K_A channel measured at the location of the synaptic input. The third column represents the gating variables of the K_A channel. The black line represents activation and the red line inactivation. A. Fast ripple with no K_A present. Input represents higher synchronicity levels present during high potassium concentration conditions. B. Fast ripple with K_A present. Note the reduction in number of action potentials generated due to the increase in K_A current. The plot of gating variables show that this input leads to a larger degree of activation, particularly at its peaks and to a lesser degree of inactivation, particularly for later inputs. C. Control input representing lower synchronicity present in control concentration of potassium.