Table 4.
Material Properties (mean ± standard deviations)
| Age (months) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 4 | 6 | ANOVA | ||||||
| Tissue Mineral Density (mgHA/cm3) | TR | 1045.32** | (13.99) | 1194.43*** | (17.99) | 1270.07 | (38.56) | 1302.30 | (25.90) | a,b,c |
| WT | 1014.25 | (33.18) | 1149.95 | (13.87) | 1262.49 | (13.84) | 1295.24 | (20.11) | ||
| Ultimate Stress (MPa) | TR | 104.23 | (13.67) | 157.02 | (14.41) | 187.79 | (28.17) | 185.80 | (36.11) | a |
| WT | 98.83 | (30.62) | 148.97 | (22.06) | 182.59 | (22.17) | 177.57 | (22.78) | ||
| Pre-yield Strain | TR | 0.030 | (0.005) | 0.040 | (0.012) | 0.030 | (0.007) | 0.042 | (0.008) | a |
| WT | 0.031 | (0.005) | 0.036 | (0.009) | 0.032 | (0.006) | 0.035 | (0.010) | ||
| Post-yield Strain | TR | 0.05** | (.04) | 0.03** | (.01) | 0.02 | (.01) | 0.02 | (.01) | a,b,c |
| WT | 0.14 | (.09) | 0.07 | (.03) | 0.02 | (.01) | 0.02 | (.01) | ||
| Young's Modulus (GPa) | TR | 5.20 | (1.55) | 7.62 | (1.98) | 11.20 | (2.41) | 9.49 | (2.49) | a |
| WT | 4.37 | (2.00) | 6.47 | (1.98) | 10.37 | (2.11) | 9.63 | (3.37) | ||
| Modulus of toughness (MPa) | TR | 2.25* | (4.87) | 1.31** | (1.74) | 0.57 | (.59) | 0.34 | (.22) | a,b,c |
| WT | 16.68 | (19.18) | 4.15 | (1.76) | 0.49 | (.41) | 0.61 | (.49) | ||
*
p < 0.05,
**
p < 0.01,
***
p < 0.001, vs. WT at same age
a
Two-way ANOVA significant for age (p<0.05)
b
Two-way ANOVA significant for group (p<0.05)
c
Two-way ANOVA significant for the age-by-group interaction (p<0.05)
TR = Transgenic, WT = Wild type