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. 2011 Nov 15;25(22):2374–2386. doi: 10.1101/gad.178079.111

Figure 5.

Figure 5.

CLK binding results in isoform-specific mRNA cycling. Fifty-five percent of CLK direct targets have alternative start sites. (A) CLK binds to both the short (isoform B) and long isoforms of moe at ZT14. (B) CLK binds to the short isoform (isoform B) of mnt at ZT14. (C) mRNA levels at six time points throughout the day are double-plotted and show that the mRNA resulting from isoform B of moe cycles with a peak amplitude at ZT14 (triangles; solid line). In contrast, mRNAs resulting from the longer isoforms (isoforms D–J) of moe do not cycle (squares; dashed line). (D) mRNA levels at six time points throughout the day are double-plotted and show that the mRNA resulting from isoform B of mnt cycles with a peak amplitude at ZT14 (triangles; solid line). In contrast, mRNAs resulting from the longer isoforms (isoforms A and C) of mnt do not cycle (squares; dashed line).