Fig. 1.

Effect of in vivo L-arginine supplementation on relaxation of lung parenchymal strips. Impaired relaxation of lung parenchymal strips in response to EFS was observed in rat pups exposed to moderate hyperoxia for 7 days when compared to room air controls (p < 0.01). There was significantly impaired relaxation with EFS of 45 and 50 V (both p < 0.01) in hyperoxic versus room air rat pups. In vivo supplementation of L-arginine (300 mg/kg/day) for 7 days restored the impairment of relaxation in hyperoxic pups to the room air level. RA = Room air.