Figure 5. Tmc1^Δ and Tmc2^Δ vestibular hair cell mechanotransduction currents.

(A) Representative mechanotransduction current families for utricle type II hair cells harvested between P1 and P8. Hair bundles were deflected in 250-ms steps that ranged from –0.5 μm to 1 μm in 0.1-μm increments. The envelope of the stimulus protocol is shown at the bottom left. Currents were recorded at –64 mV, a physiologically relevant holding potential. Some traces have been removed for clarity. Scale bars apply to all current families. (B) Summary bar graph from 111 type II utricle hair cells. The graph shows mean maximal mechanotransduction current amplitudes (±SEM). For each bar, the upper number indicates the number of mice examined, and the lower number indicates the total number hair cells examined for each genotype. *P < 0.001, 1-way ANOVA), relative to wild-type values.