Fig. 2.
Thymectomy and CD25 mAb differentially affect lifespan in an orthotopic GL261 cell-based mouse brain tumor model. Mice were ± thymectomized at 4 weeks of age (WOA), i.p. injected at 6.6 WOA with saline or CD25 mAb, and i.c. injected at 7 WOA with 4 × 105 GL261 cells (Supplementary Fig. S1A). The Kaplan–Meier curve represents mouse survival times over a course of 76 days. The control group received an i.c. injection of saline alone (n = 5). The remaining 4 groups (n = 10–12 per group) received 1 or more of the following: thymectomy; an i.p. injection of saline or CD25 mAb; and an i.c. injection of 4 × 105 GL261 cells.