Table 5.
Application of the proposed method for determination of the studied drugs in their co-formulated preparation
| Preparation | Concentration taken (μg/mL) | Concentration found (μg/mL) | Recovery % | Comparison method (4) | ||||
|---|---|---|---|---|---|---|---|---|
| MTP | FDP | MTP | FDP | MTP | FDP | MTP | FDP | |
| Logimax® Tabletsa | 5.0 | 0.5 | 4.919 | 0.503 | 98.37 | 100.62 | 98.82 | 99.36 |
| (MTP 50 mg + FDP 5 mg/Tablet) | 8.0 | 0.8 | 7.927 | 0.813 | 99.09 | 101.65 | 101.79 | 100.84 |
| Batch # 604346 | 10.0 | 1.0 | 9.907 | 1.002 | 99.07 | 100.17 | 99.28 | 99.69 |
| (x) | 98.84 | 100.81 | 99.96 | 99.96 | ||||
| ± SD | ± 0.41 | ± 0.759 | ± 1.6 | ± 0.78 | ||||
| % RSD | 0.415 | 0.753 | ||||||
| % Error | 0.24 | 0.435 | ||||||
| t | 1.18 (2.78) | 1.36(2.78) | ||||||
| F | 15.2 (19) | 1.05 (19) | ||||||
• Each result is the average of three separate determinations. aProduct of Astra Zeneca.
• Figures between parenthesis are the tabulated t (at degree of freedom = 4 for both drugs) and F values (at degree of freedom = 2, 2 for both drugs), respectively at p = 0.05 [11].