Table 4. Association between KLK15 rs2659056 SNP and prostate tumour aggressiveness in five different study groups, using a case-case analysis.
| SNP | Controls | Non-aggressive cases (GS<7) | Aggressive cases (GS≥7) | OR (95 CI) Aggressive vs Non-aggressive) | P value |
| Australian dataset (ncases = 862, ncontrol = 1375) a | |||||
| TT | 758 (55.1) | 111 (44.0) | 343 (56.2) | ||
| TC | 527 (38.3) | 118 (46.8) | 228 (37.4) | 0.70 (0.56–0.89) | 0.003 |
| CC | 90 (6.5) | 23 (9.1) | 39 (6.4) | ||
| UK GWAS Stage 1 (ncases = 1232 ncontrol = 1894) b | |||||
| TT | 1166 (61.6) | 368 (55.1) | 298 (52.8) | ||
| TC | 650 (34.3) | 250 (37.4) | 224 (39.7) | 1.06 (0.89–1.26) | 0.54 |
| CC | 78 (4.1) | 50 (7.5) | 42 (7.4) | ||
| UK GWAS Stage 2 (ncases = 2343, ncontrol = 3936) b | |||||
| TT | 2164 (55) | 680 (55.3) | 606 (54.4) | ||
| TC | 1510 (38.4) | 478 (38.9) | 443 (39.8) | 1.03 (0.9–1.17) | 0.71 |
| CC | 262 (6.7) | 71 (5.8) | 65 (5.8) | ||
| UK GWAS Stage 3 (ncases = 3041, ncontrol = 4165) b | |||||
| TT | 2346 (56.3) | 771 (52.3) | 875 (56.0) | ||
| TC | 1536 (36.9) | 584 (39.6) | 595 (37.9) | 0.87 (0.78–0.98) | 0.020 |
| CC | 283 (6.8) | 119 (8.0) | 97 (6.1) | ||
| CGEMS (ncases = 1148; ncontrol = 1145) c | |||||
| TT | 624 (54.5) | 259 (53.0) | 359 (54.5) | ||
| TC | 443 (38.7) | 194 (39.7) | 261 (39.6) | 0.93 (0.77–1.12) | 0.43 |
| CC | 78 (6.8) | 36 (7.4) | 39 (5.9) | ||
| Combined Results (ncases = 8,626; ncontrol = 12,515) c | |||||
| TT | 7058 (56.4) | 2189 (53.2) | 2481 (55.0) | ||
| TC | 4666 (37.3) | 1624 (39.5) | 1751 (38.8) | 0.92 (0.86–0.98) | 0.017 |
| CC | 791 (6.3) | 299 (7.3) | 282 (6.2) | ||
| Combined Results with studies selected on heterogeneity test (ncases = 5,051; ncontrol = 6,685) c | |||||
| TT | 3728 (55.8) | 1141 (51.5) | 1577 (55.6) | ||
| TC | 2506 (37.5) | 896 (40.5) | 1084 (38.2) | 0.85 (0.77–0.93) | 2.7×10−4 |
| CC | 451 (6.7) | 178 (8.0) | 175 (6.2) | ||
a
The result of trend test based on logistic regression adjusted for age as continuous variable.
b
UK dataset adjusted for study group (categorical) and age (continuous.)
c
Adjusted for study group and age as categorical variable.
ncases = total no of patients; ncontrol = total no of controls.