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. 2011 Nov 23;6(11):e27372. doi: 10.1371/journal.pone.0027372

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Caskey et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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H&E stained histology of MET-1 tumors. (a) H&E stained section of a single tumor (T) with multiple cysts (C) growing beneath the dermis (D) in the mammary fat pad (F). (b) The epidermis (E), dermis (D), fat pad fascia (FP) and fat (F) remote to the tumor has minimal inflammation. (c) In contrast, the fat pad (F) adjacent to the tumor (T) is inflamed with compressed adipocytes, dilated, engorged vessels (V) and scattered granulocytes (g). (d) The malignant nature of the tumor is illustrated by the cords of neoplastic cells infiltrating the adjacent fat (f) and connective tissue (ct).