Table 1. Sequence information of the RT sequences in the data set.

Residue/Sequence	89	100	101	102	103	106	118	162	169	179	181	188	190	203	207	210	211	214	215	219	227	234	245	138 (b)	Mean pEC50	pEC50 (sd)	n
1	A	L	K	K	K	V	V	S	E	V	Y	Y	G	E	Q	L	R	L	T	K	F	L	V	E	8.3	0.6	451
2										F	C														6.9	0.7	259
3											C														7.6	0.6	444
4					N						C														7.5	0.7	443
5		I			N																				7.4	0.8	429
6		I			N					I	C							F						G	6.0	0.6	316
7	S		P	R			I				C		A	V	E	W		F	Y	N			I		6.5	0.6	99
8			P																						6.9	0.7	147
9					N																				8.3	0.6	222
10		I																							7.9	0.7	252
11								K				L													7.5	0.7	257
12			E		N																				8.0	0.6	242
13																					C	I			7.4	0.8	244
14						A			G												L				8.2	0.8	220

Sequence 1 is wild type RT. The other sequences contained one or multiple point mutations of the binding site residues. The mean pEC₅₀ of the compounds tested on the sequence is given as is the standard deviation of the series of compounds tested on the sequence. n indicates the number of compounds tested on a particular sequence. Residue number 138 is located on the b-chain of RT while the other residues are located on the a-chain.