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. 2011 Nov 23;6(11):e27639. doi: 10.1371/journal.pone.0027639

Figure 3. Schematic representation of CML protection assays.

Figure 3

(A) NK cell rejection of normal BM allografts is lethal between d12 and d14 post transplantation. To ensure the survival of host mice beyond this time point, lethally irradiated recipient mice were transplanted with mixtures of MHC-I matched rescue BM plus MHC-I-different BCR-ABL1 transduced BM. (B) Mixed BM grafts rapidly induces CML disease, which is characterized by pulmonary hemorrhage, splenomegaly and increased numbers of mature granulocytes in peripheral blood.